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GRP109a is expressed in macrophages, other immune cells, adipocytes, as well as pancreatic β cells (Wang et al., 2016), and activation of the receptor has been shown to have an anti-inflammatory and anti-carcinogenic effect in the intestine (Thangaraju et al., 2009

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Future studies should explore its serotonergic activity, long-term safety, and efficacy in diverse TRD models